… It is a manufactured ∼8 nm nanoparticle with bovine … artery could limit cerebral blood flow
after TBI and catheterization … D), and percent of carboxyhemoglobin (E) in whole blood for pigs …

… PEGylation increases the molecular size and colloid oncotic … significant increase in
carboxyhemoglobin levels. This … Alternatively, Sanguinate’s increase in regional cerebral blood …

… ) induces redistribution of cerebral blood flow (CBF) and … PP‐007 (formerly known as
SANGUINATE), a carbon … revealed that this increase in PTT was most likely a pegylation process‐…

… substitutes that are currently undergoing testing, known as PEGylated … They were made
using outdated human or bovine blood, … Sanguinate has been granted orphan drug status for …

… the use of Sanguinate, a bovinederived artificial oxygen carrier, … The team reported a
16% rise in regional cerebral blood flow … PEGylated bovine carboxyhemoglobin (SANGUINATE™): …

… is to increase cerebral blood flow (CBF) in regions that are … , making the brain more susceptible
to hypoxic/ischemic injury [… Sanguinate™, SG) is a PEGylated carboxyhemoglobin (PEG-…

… Sanguinate is PEGylated bovine carboxyhemoglobin, which … is in the treatment of subarachnoid
hemorrhage (SAH). Dhar … , Sanguinate administration improved cerebral blood flow (…

… The CoW can provide immediate diversion of blood flow in … Sanguinate™, SG) is a
PEGylated carboxyhemoglobin (PEG-… effects on the brain and cerebral circulation. Its protective …

… improves cerebral blood flow to vulnerable brain regions at risk of delayed cerebral ischemia
after subarachnoid … PEGylated carboxyhemoglobin bovine (SANGUINATE): results of a …

… curve, an increased viscosity and a PEGylated coat surrounding a small Hb-based …
subarachnoid hemorrhage treated with Sanguinate, an improvement in regional cerebral blood flow …